Renal tubular damage as an independent risk factor for all-cause and cardiovascular mortality in a community-based population: the Takahata study.

ABSTRACT:

Background

Renal tubular damage plays a crucial role in the development of end-stage kidney disease, a risk factor for cardiovascular events and mortality. However, the relationship between renal tubular damage and all-cause and cardiovascular mortality rates in the general population remains unclear. To address this gap, we conducted a cohort study in the general population using the urinary β2-microglobulin-creatinine ratio (UBCR) as a marker of renal tubular damage.

Methods

This study included 3427 residents aged ≥ 40 years in Takahata, Japan. We examined the association between the UBCR values in single-spot urine samples at enrollment and all-cause and cardiovascular mortality rates within a median follow-up of 9.2 years.

Results

The participants were divided int

SUBMITTER: Suzuki T 

PROVIDER: S-EPMC11937237 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature