Agarwood leaf ethanol extract provides neuroprotective properties and promotes cholinergic differentiation of HT22 hippocampal neurons.

ABSTRACT: Neurodegenerative diseases, characterized by the loss or damage of neurons, represent a growing global health concern. Plants are a rich source of naturally occurring compounds with immense therapeutic potential. Among them, Aquilaria crassna (commonly known as agarwood) is a precious fragrant plant extensively used in cosmetics, perfumes, and traditional Asian medicine. However, its neuroprotective role, particularly in neuroregeneration, has been minimally explored. This study aimed to investigate the therapeutic potential of agarwood leaves in promoting neuroregeneration, with a focus on cholinergic function and neural differentiation. To identify bioactive compounds, a comprehensive LC-MS analysis was conducted on agarwood ethanolic extract (AWE). The phytochemicals detected were furth

SUBMITTER: Kumaree KK 

PROVIDER: S-EPMC11937462 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature