Overexpression of βTrCP1 elicits cell death in cisplatin-induced senescent cells.

ABSTRACT: Senescence is a non-proliferative cellular state derived from aging or in response to exogenous insults, such as those that cause DNA damage. As a result of cancer treatments like cisplatin, certain tumor cells may undergo senescence. However, rather than being beneficial for patients, this is detrimental because these cells might proliferate again under specific conditions and, more importantly, because they synthesize and secrete molecules that promote the proliferation of nearby cells. Therefore, to achieve complete tumor remission, it is necessary to develop senolytic compounds to eliminate senescent cells. Here, we studied the role of βTrCP1 in cell proliferation and senescence and found that lentiviral overexpression of βTrCP1 induces the death of senescent cells obtained after cispl

SUBMITTER: Belmonte-Fernandez A 

PROVIDER: S-EPMC11937513 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature