Aerobic Exercise Training, Biological Age, and Mortality in Chronic Heart Failure With Reduced Ejection Fraction.

ABSTRACT:

Background

Among individuals with chronic heart failure with reduced ejection fraction (HFrEF), the predictive value for mortality by biomarker-based biological age (BA) and whether aerobic exercise training (AET) modifies the association are understudied.

Objectives

The authors aimed to investigate the association between BA and mortality among individuals with HFrEF and assess whether AET modifies the association.

Methods

Including participants in HF-ACTION (Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training), BA acceleration was constructed by the Klemera-Doubal method, using the residual of a linear model of BA and chronological age. The associations between BA and all-cause mortality, cardiovascular death, and all-cause hospitalization

SUBMITTER: Huang Z 

PROVIDER: S-EPMC11937671 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature