Stabilization of a Terminal Hydride Through Regioselective Protonation in a Diiron Complex Inspired by [FeFe]-Hydrogenase.

ABSTRACT: Protonation studies of the complex [Fe₂(μ-pdt)(κ²-dmpe)₂(CO)₂] (1), inspired by the [FeFe]-hydrogenases active site cofactor, yield terminal and bridging hydrido isomers in a ratio that depends on the acid strength and steric hindrance. A terminal hydride ligand is mainly obtained in presence of weaker acids such as [HP^tBu₃][BF₄] and [HNEt₃][BF₄] while a bridging isomer is predominantly formed with stronger acids such as [HPPh₃][BF₄] and [H(OEt₂)][BF₄]. The terminal isomer is comparatively stable and undergoes isomerization into the bridging hydride following first-order kinetics, with half-lives of 21 days and 3 days at room temperature and 40 °C,

SUBMITTER: Chatelain L 

PROVIDER: S-EPMC11937869 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature