Time-restricted eating, caloric reduction, and unrestricted eating effects on weight and metabolism: a randomized trial.

ABSTRACT:

Objective

Metabolic improvements may precede weight loss. We compared the effects of self-selected 8-h time-restricted eating (TRE), 15% caloric restriction (CR), and unrestricted eating (UE) on weight, body composition, caloric intake, glycemic measures, and metabolic flexibility.

Methods

In this 12-week randomized-controlled trial, we measured weight (primary outcome), body composition (dual-energy x-ray absorptiometry/magnetic resonance imaging), caloric intake (24-h recall), metabolic flexibility (indirect calorimetry during hyperinsulinemic-euglycemic clamp), and glycemic measures (hemoglobin A1c, hyperinsulinemic-euglycemic clamp, continuous glucose monitoring).

Results

Of the 88 enrolled participants, 81 (92%) completed the trial (mean [SD], age, 43.2 [10.5] ye

SUBMITTER: Oldenburg N 

PROVIDER: S-EPMC11937878 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature