Differences Between Patients With Multiple System Atrophy With Predominant Parkinsonism and Parkinson's Disease Based on fNIRS and Gait Analysis.

ABSTRACT:

Objective

To investigate the differences in gait parameters and cortical activity during a single-task walking (STW) and cognitive dual-task walking (DTW) between multiple system atrophy with predominant parkinsonism (MSA-P) and Parkinson's disease (PD).

Methods

24 MSA-P patients, 20 PD patients, and 22 healthy controls (HCs) were enrolled. Gait parameters were collected using a portable inertial measurement unit system, and the relative change of oxyhemoglobin (ΔHbO₂) in the bilateral frontal and sensorimotor cortex was obtained by functional near-infrared spectroscopy during walking with and without cognitive tasks.

Results

MSA-P patients had increased step length variability and higher ΔHbO₂ in the right dorsolateral prefrontal cortex (DLPFC),

SUBMITTER: Gao M 

PROVIDER: S-EPMC11937913 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature