AlphaPulldown2-a general pipeline for high-throughput structural modeling.

ABSTRACT:

Summary

AlphaPulldown2 streamlines protein structural modeling by automating workflows, improving code adaptability, and optimizing data management for large-scale applications. It introduces an automated Snakemake pipeline, compressed data storage, support for additional modeling backends like UniFold and AlphaLink2, and a range of other improvements. These upgrades make AlphaPulldown2 a versatile platform for predicting both binary interactions and complex multi-unit assemblies.

Availability and implementation

AlphaPulldown2 is freely available at https://github.com/KosinskiLab/AlphaPulldown.

SUBMITTER: Molodenskiy D 

PROVIDER: S-EPMC11937959 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature