Catalyst-Transfer Macrocyclization Protocol: Synthesis of π-Conjugated Azaparacyclophanes Made Easy.

ABSTRACT: The present Protocol describes the application of the catalyst-transfer macrocyclization (CTM) reaction, focusing on the synthesis of aza[1_n]paracyclophanes (APCs). APCs are fully π-conjugated shape-persistent macrocycles with potential supramolecular chemistry and materials science applications. This method leverages the Pd-catalyzed Buchwald-Hartwig cross-coupling reaction to selectively form π-conjugated cyclic structures, a significant advancement due to its efficiency, versatility, and scalability. Overall, this Article highlights the following attributes of the CTM method: a) Efficiency and Yield: The CTM method works at mild temperatures (40 °C) and short reaction times (≥2 h), producing high yields of APCs (>75% macrocycles). It avoids the typical high-dilution condition

SUBMITTER: Ayuso-Carrillo J 

PROVIDER: S-EPMC11937971 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature