Immobilization by 21-days of bed rest causes changes in biomarkers of cartilage homeostasis in healthy individuals.

ABSTRACT:

Objective

To investigate the effects of 21 days bed rest immobilization (with and without exercise and nutrition intervention) on serum concentrations of cartilage homeostasis biomarkers in healthy individuals.

Design

Twelve male volunteers (age 34.2 ​± ​8.3 years; BMI 22.4 ​± ​1.7 ​kg/m²) participated in 6 days of baseline data collection (BDC), 21 days of 6° head-down-tilt (HDT) bed rest (CON) ​+ ​interventions HDT ​+ ​resistive vibration exercise (RVE; 2 times/week; 25 ​min) and HDT ​+ ​RVE ​+ ​nutrition (NeX; 0.6 ​g/kg body weight/day whey protein and 90 ​mmol KHCO₃/day bicarbonate supplementation), and 6 days of recovery (R) in a cross-over designed study. The starting HDT condition was randomized (CON-RVE-NeX, RVE-NeX-CON, NeX-CON-RVE). Blood samp

SUBMITTER: Dreiner M 

PROVIDER: S-EPMC11938040 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature