Pyridostigmine in the management of orthostatic hypotension: a systematic review and meta-analysis.

ABSTRACT:

Background

Current pharmacological approaches for the treatment of orthostatic hypotension (OH) may detrimentally affect supine blood pressure (BP). This side effect is often unacceptable and limits the utility of medical management. Pyridostigmine has been proposed as a potential treatment alternative which may improve OH without worsening supine hypertension. This systematic review and meta-analysis aimed to evaluate the currently available data regarding the use of pyridostigmine in the treatment of all-cause OH.

Methods

A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. PubMed, EMBASE, Cochrane and SCOPUS were searched for publications until 4 June 2024. A random-effects model was used f

SUBMITTER: Pavic NV 

PROVIDER: S-EPMC11938227 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature