Magnitude and Predictors of the Placebo Effects in the Dry Eye Assessment and Management Study.

ABSTRACT:

Purpose

To determine the magnitude and predictors of placebo effects on dry eye symptoms and signs in the Dry Eye Assessment and Management (DREAM) study.

Design

Secondary analysis of data from the DREAM study, a large-scale multicenter randomized clinical trial of patients with moderate to severe dry eye disease (DED).

Participants

One hundred sixty-four participants who were randomized to the placebo group (daily oral 1000 mg refined olive oil) and completed a 12-month follow-up in 27 United States centers.

Methods

At baseline, 3, 6, and 12 months, DED symptoms were evaluated using the Ocular Surface Disease Index (OSDI), and signs were assessed using conjunctival staining, corneal staining, tear break-up time (TBUT), Schirmer test, and meibomian gland dysfun

SUBMITTER: Han K 

PROVIDER: S-EPMC11938258 | biostudies-literature | 2025 May-Jun

REPOSITORIES: biostudies-literature