Apolipoprotein A-IV is induced by high-fat diets and mediates positive effects on glucose and lipid metabolism.

ABSTRACT:

Objective

Low-carbohydrate, high-fat diets under eucaloric conditions are associated with several health-beneficial metabolic effects in humans, particularly in the liver. We recently observed that apolipoprotein A-IV (apoA-IV), a highly abundant apolipoprotein, was among the most upregulated proteins in circulation after six weeks of consuming a high-fat diet in humans. However, the impact of dietary changes in regulating apoA-IV, and the potential effects of apoA-IV on regulation of glucose- and lipid metabolism remain to be fully established.

Methods

We investigated the regulation of circulating fasting concentrations of apoA-IV in humans in response to diets enriched in either fat or carbohydrates. Moreover, to study the whole-body and tissue-specific glucose and lipid m

SUBMITTER: Lundsgaard AM 

PROVIDER: S-EPMC11938269 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature