Brain morphology mediating the effects of common genetic risk variants on Alzheimer's disease.

ABSTRACT:

Background

Late-onset Alzheimer's disease (LOAD) has been associated with alterations in the morphology of multiple brain structures, and it is likely that disease mechanisms differ between brain regions. Coupling genetic determinants of LOAD with measures of brain morphology could localize and identify primary causal neurobiological pathways.

Objective

To determine causal pathways from genetic risk variants of LOAD via brain morphology to LOAD.

Methods

Mediation and Mendelian randomization (MR) analysis were performed using common genetic variation, T1 MRI and clinical data collected by UK Biobank and Alzheimer's Disease Neuroimaging Initiative.

Results

Thickness of the entorhinal cortex and the volumes of the hippocampus, amygdala and inferior lateral ventric

SUBMITTER: Breddels EM 

PROVIDER: S-EPMC11938454 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature