Application of metagenomic next-generation sequencing in treatment guidance for deep neck space abscess.

ABSTRACT:

Background

Infectious etiologies of deep neck space abscess (DNSA) by conventional culture tests can be challenging, which also leads to frequent irrational antibiotic usage. Metagenomic next-generation sequencing (mNGS), as a novel method for analyzing the complex microbial ecosystem from clinical samples, has been utilized in clinical research and practice of various infectious diseases but deep neck space abscess. We here aimed to explore the clinical value of mNGS for pathogen detection and treatment guidance in DNSA patients compared with conventional culture tests.

Methods

One hundred six patients diagnosed with DNSA were retrospectively enrolled and allocated into mNGS group and culture group according to whether mNGS was conducted. The pathogen detection effectivenes

SUBMITTER: Lei H 

PROVIDER: S-EPMC11938550 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature