Genetic susceptibility to essential hypertension in the Chinese han population: a study on GAB1, GAB2, and GAB3 gene polymorphisms.

ABSTRACT:

Background

This study aims to examine the association between single nucleotide gene polymorphisms (SNPs) of GAB1, GAB2, and GAB3 and the genetic susceptibility to essential hypertension in the Chinese Han population. The findings of this research will contribute to understanding the underlying causes of hypertension.

Methods

A community-based sampling survey was conducted in two towns in the south of Jiangsu Province to investigate the correlation between gene polymorphisms and essential hypertension. The study included a total of 2119 cases of hypertension and 2317 healthy controls, with an average follow-up period of 10.75 years. The genotypes of seven tagging SNPs (GAB1 rs300893 and rs11936966, GAB2 rs7107174, rs2450135, and rs3740677, GAB3 rs3813455 and rs5987015) were

SUBMITTER: Xiong J 

PROVIDER: S-EPMC11938551 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature