Candidate target genes in sepsis diagnosis and therapy: identifying hub genes with a spotlight on KLRB1.

ABSTRACT:

Background

Sepsis, which causes systemic inflammation and organ failure, is one of the leading causes of death in the intensive care unit (ICU) and an urgent social health problem. However, the pathogenesis and molecular mechanism of sepsis are unclear. Therefore, this study aimed to identify candidate Hub genes during sepsis progression and the candidate target genes for sepsis diagnosis and treatment.

Methods

GSE54514, GSE57065, GSE69528, GSE95233, and GSE131761 datasets were downloaded from public databases, and the differentially expressed genes (DEGs) between healthy and septic patients in each dataset were screened at adjusted P-value < 0.05 and| log2FC| ≥ 0.58. Subsequently, the obtained DEGs in each dataset were intersected to obtain the Hub genes. In addition, the D

SUBMITTER: Chen W 

PROVIDER: S-EPMC11938612 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature