Initial and peak serum levels of Krebs von den Lungen-6 for predicting the prognosis of patients with COVID-19.

ABSTRACT:

Background/aims

Krebs von den Lungen-6 (KL-6) is associated with prognosis in patients with COVID-19. However, there is limited data on the correlation between the prognosis of COVID-19 and varying KL-6 levels at different time points. We investigated the optimal cutoff values of the initial and peak serum KL-6 levels to predict mortality and evaluated their correlation with mortality.

Methods

This retrospective cohort study collected data on serially collected serum KL-6 levels in patients hospitalized with COVID-19 between October 2020 and January 2022 at a single tertiary hospital in South Korea. The area under the receiver operating characteristic curve and Youden index were used to determine the cutoff points for the initial and peak KL-6 levels that best predicted 30-d

SUBMITTER: Kim G 

PROVIDER: S-EPMC11938661 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature