Longitudinal trajectories of subjective cognitive complaints in patients with major depressive disorder and similar objective cognitive trajectories.

ABSTRACT:

Background

We examined the factors influencing various subtypes of subjective cognitive change in patients who shared similar objective cognitive trajectories within 6 months.

Method

We used data from an observational, prospective, cohort study, including 598 patients with major depressive disorder (MDD) in latent class mixed models based on the digit symbol substitution test performance. Participants were stratified into four distinct objective cognitive layers: "low cognitive performance," "lower-middle cognitive performance," "upper-middle cognitive performance," and "high cognitive performance." Within each of the four layers, the trajectories of subjective cognitive complaints were identified. Multinomial regression was employed, with cognitive complaint trajectories as

SUBMITTER: Zhu X 

PROVIDER: S-EPMC11938668 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature