Graph theory analysis reveals functional brain network alterations in HIV-associated asymptomatic neurocognitive impairment in virally suppressed homosexual males.

ABSTRACT:

Background

This study aimed to investigate the global and nodal functional network alterations, abnormal connections of brain regions, and potential imaging biomarkers in virally suppressed people living with HIV (PLH) with asymptomatic neurocognitive impairment (ANI) using graph theory analysis.

Methods

The study included 64 men with ANI (mean age 32.45 years) and 64 healthy controls (HC) (mean age 31.31 years). The functional network was established through the graph theory method and Automated Anatomic Labeling (AAL) 90 atlas, which provides a cerebrum parcellation framework. Moreover, hub regions were identified based on betweenness centrality (Bc). Functional connectivity (FC) differences were investigated between the two groups, these connections were located in the re

SUBMITTER: Aili X 

PROVIDER: S-EPMC11938670 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature