The effect of Rsk2 on TNFα-mediated bone loss in the TMJ and craniofacial skeleton.

ABSTRACT:

Objectives

This study aims to investigate the impact of the pro-osteoblastogenic ERK-activated ribosomal S6 kinase (Rsk2) on Tumor necrosis factor (TNF)α-induced bone loss in the craniofacial system, focusing on its role in rheumatoid arthritis (RA). The objective is to understand whether Rsk2, previously shown to have protective effects in long bones against TNFα-induced bone resorption, exhibits similar effects in the craniofacial region.

Materials

, and Methods. The study compares mice with TNFα overexpression, Rsk2 knockout mice, and a combination of TNFα, and Rsk2 knockout mice using detailed micro-computed tomography coupled with landmark based morphometric analysis, and classical histology. The overall skull morphology, mandible shape, and the temporomandibular joint

SUBMITTER: Georgi GM 

PROVIDER: S-EPMC11938757 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature