Altered oral health and microbiota in drug-free patients with schizophrenia.

ABSTRACT:

Background

The oral microbiota is associated with neuro-psychiatric disorders. However, there is presently inadequate comprehension regarding the correlation between schizophrenia and the oral microbiota. Moreover, patients with schizophrenia frequently exhibit poor oral health, potentially influencing research outcomes. Therefore, this study aims to investigate changes in the oral microbiota and oral health status in drug-free schizophrenia patients.

Methods

Oral microbiota samples were collected from 50 drug-free patients with schizophrenia and 50 healthy controls (HCs). The downstream microbiota analysis was based on Illumina sequencing of the V3-V4 hypervariable region of the 16 S rRNA gene.

Results

The alpha diversity of SCZ group is increased, such as the Shanno

SUBMITTER: Huang H 

PROVIDER: S-EPMC11938765 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature