Lung IL-13 gene signatures are associated with raised tissue eosinophils in COPD.

ABSTRACT:

Background

The role of eosinophils in COPD and their utility as biomarkers for cytokine targeting monoclonal therapies remains unclear. We investigated the distribution of eosinophils across different tissue compartments in COPD and analysed gene expression to understand the possible mechanistic drivers of eosinophilic inflammation in COPD.

Methods

Blood and BAL from ex-smoking volunteers with mild/moderate COPD (n = 31) and healthy ex-smoking controls (n = 20), and bronchial biopsy tissue in a subcohort (n = 19 and n = 8, respectively) was analysed. Differentially-expressed genes (DEGs) were characterised using RNASeq. Proteomic analysis of BAL was conducted using mass-spectrometry.

Results

COPD subjects had more eosinophils in blood and lung tissue compared to contr

SUBMITTER: Staples KJ 

PROVIDER: S-EPMC11938775 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature