The Chinese gut virus catalogue reveals gut virome diversity and disease-related viral signatures.

ABSTRACT:

Background

The gut viral community has been increasingly recognized for its role in human physiology and health; however, our understanding of its genetic makeup, functional potential, and disease associations remains incomplete.

Methods

In this study, we collected 11,286 bulk or viral metagenomes from fecal samples across large-scale Chinese populations to establish a Chinese Gut Virus Catalogue (cnGVC) using a de novo virus identification approach. We then examined the diversity and compositional patterns of the gut virome in relation to common diseases by analyzing 6311 bulk metagenomes representing 28 disease or unhealthy states.

Results

The cnGVC contains 93,462 nonredundant viral genomes, with over 70% of these being novel viruses not included in existing gut vi

SUBMITTER: Yan Q 

PROVIDER: S-EPMC11938785 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature