The potential of <i>Abrus precatorius</i> leaves in arthritis alleviation computational approaches through lC-MS analysis.

ABSTRACT:

Aim

This study explores the therapeutic potential of Abrus precatorius leaves in arthritis treatment using computational methods and LC-MS analysis.

Methods

The plant material was taxonomically authenticated, and phytochemical analysis identified bioactive compounds such as alkaloids, flavonoids, and triterpenoids.

Results

Swiss ADME analysis confirmed that multiple compounds complied with Lipinski's Rule of Five, while OSIRIS software indicated minimal toxicity. PASS analysis predicted anti-inflammatory and antioxidant activities. Molecular docking simulations of Abrine with key rheumatoid arthritis (RA) targets revealed strong binding affinities, suggesting potential mechanisms for RA treatment.

Conclusion

This research highlights the medicinal potenti

SUBMITTER: Vijayan S 

PROVIDER: S-EPMC11938972 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature