Systemic antitumor immune response of doped yttria nanoscintillators under low-dose x-ray irradiation.

ABSTRACT: Inadequate light penetration in tissues restricts photodynamic therapy to treating only superficial tumors. To enable x-ray-excited photodynamic therapy (XPDT) that targets deep-seated tumors, we synthesized a nanoscintillator-photosensitizer complex containing 5% Eu-doped Y₂O₃ fluorescing at 611 nanometers and decorated with SiO₂ containing the scintillation-coupled photosensitizer methylene blue and a polyethylene glycol coating [PEGylated Y₂O₃:Eu@SiO₂-methylene blue (pYSM)]. When irradiated, pYSMs generate singlet oxygen species in vitro, causing cytotoxicity with hallmarks of immunogenic cell death (calreticulin translocation to the cell membrane). Intravenously administered pYSMs home passively to pancreatic tumor xenog

SUBMITTER: Sahin O 

PROVIDER: S-EPMC11939067 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature