Examining risk assessment implications of genetic and dose-dependent dynamics of lead exposure in breastfeeding using the collaborative cross mouse population.

ABSTRACT: Breastfeeding offers well-documented advantages but may inadvertently introduce lead (Pb) exposure to infants. Scarce data exist on the risks of Pb exposure for breastfed infants, and strategies for risk mitigation are needed, particularly considering the heightened susceptibility of children to adverse effects from Pb exposure. To investigate the potential influence of breastfeeding on blood Pb levels (BLL) in offspring, population variation in BLL between nonparous and parous mouse dams was quantified, as well as in dams exposed to low and high dose while breastfeeding, and their offspring. Female mice from 14 distinct collaborative cross (CC) mouse strains were mated with sires from different CC strains to produce 14 F1 hybrids. Subsequently, dams were administered either low- (100 ppm)

SUBMITTER: Cuomo D 

PROVIDER: S-EPMC11939076 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature