Treatment of Ebola Virus Disease: From Serotherapy to the Use of Monoclonal Antibodies.

ABSTRACT: Ebola virus disease (EVD) is an acute illness with a high-case fatality rate (CFR) caused by an RNA virus belonging to the Filoviridae family. Over the past 50 years, regular EVD outbreaks have been reported. The West African EVD outbreak of 2013-2016 proved to be significantly more widespread and complex than previous ones, resulting in approximately 11,000 deaths. A coordinated international effort was required to bring the outbreak under control. One of the main challenges faced by clinicians and researchers combating EVD was the absence of vaccines and preventive treatments. Only recently have efforts led to the development of effective therapeutic options. Among these, monoclonal antibody-based drugs have emerged as the most promising agents for the urgent treatment of EVD. This artic

SUBMITTER: Shcherbakov DN 

PROVIDER: S-EPMC11939263 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature