Sauchinone Ameliorates Senescence Through Reducing Mitochondrial ROS Production.

ABSTRACT: One of the major causes of senescence is oxidative stress caused by ROS, which is mainly generated from dysfunctional mitochondria. Strategies to limit mitochondrial ROS production are considered important for reversing senescence, but effective approaches to reduce them have not yet been developed. In this study, we screened the secondary metabolites that plants produce under oxidative stress and discovered sauchinone as a potential candidate. Sauchinone induced mitochondrial function recovery, enabling efficient electron transport within the electron transport chain (ETC). This led to a decrease in ROS production, a byproduct of inefficient electron transport. The reduction in ROS by sauchinone rejuvenated senescence-associated phenotypes. To understand the underlying mechanism by which

SUBMITTER: Kuk MU 

PROVIDER: S-EPMC11939387 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature