Predictive Model of Gemtuzumab Ozogamicin Response in Childhood Acute Myeloid Leukemia on Event-Free Survival: Data Analysis Based on Trial AAML0531.

ABSTRACT: Purpose: We aimed to develop a simple nomogram and online calculator that can identify the optimal subpopulation of pediatric acute myeloid leukemia (AML) patients who would benefit most from gemtuzumab ozogamicin (GO) therapy. Methods: Within the framework of the phase Ⅲ AAML0531 randomized trial for GO, the event-free survival (EFS) probability was calculated using a predictor-based nomogram to evaluate GO treatment impact on EFS in relation to baseline characteristics. Nomogram performance was assessed by the area under the receiver operating characteristic curve (AUC) and the calibration curve with 500 bootstrap resample validations. Decision curve analysis (DCA) was performed to evaluate the clinical utility of the nomogram. Results: A total of 705 patients were r

SUBMITTER: Qiu KY 

PROVIDER: S-EPMC11939501 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature