Impact of Glucose, Inflammation and Phytochemicals on <i>ACE2</i>, <i>TMPRSS2</i> and Glucose Transporter Gene Expression in Human Intestinal Cells.

ABSTRACT: Inflammation is associated with the pathophysiology of type 2 diabetes and COVID-19. Phytochemicals have the potential to modulate inflammation, expression of SARS-CoV-2 viral entry receptors (angiotensin-converting enzyme 2 (ACE2) and transmembrane protease, serine 2 (TMPRSS2)) and glucose transport in the gut. This study assessed the impact of phytochemicals on these processes. We screened 12 phytochemicals alongside 10 pharmaceuticals and three plant extracts, selected for known or hypothesised effects on the SARS-CoV-2 receptors and COVID-19 risk, for their effects on the expression of ACE2 or TMPRSS2 in differentiated Caco-2/TC7 human intestinal epithelial cells. Genistein, apigenin, artemisinin and sulforaphane were the most promising ones, as assessed by the downregula

SUBMITTER: Visvanathan R 

PROVIDER: S-EPMC11939507 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature