Lycorine Pre-Treatment Alleviates Microglia Inflammation After Cerebral Ischemia by Inhibiting NF-κB Phosphorylation.

ABSTRACT:

Background

Middle-aged and elderly individuals may experience detrimental health effects due to ischemic stroke (IS). The inflammatory response triggered during IS exacerbates neuronal damage, becoming a barrier to effective IS treatment and leading to poor patient prognosis. Nevertheless, the specific role of microglia in the inflammatory response triggered by IS remains mostly unclear. The primary target of this investigation is to study the neuroinflammatory impact of lycorine (LYC) during the IS process. Our objective is to evaluate whether LYC deploys its anti-inflammatory effect with modulation of the NF-κB signaling pathway, thereby reducing IS symptoms.

Methods

In this research, BV-2 cells were pre-treated with LYC for 24 h before LPS was added to induce inflammation

SUBMITTER: Zheng W 

PROVIDER: S-EPMC11939849 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature