Antimicrobial Activity of the Peptide C14R Against Ab Initio Growing and Preformed Biofilms of <i>Candida albicans</i>, <i>Candida parapsilosis</i> and <i>Candidozyma auris</i>.

ABSTRACT: Biofilms are the predominant lifeforms of microorganisms, contributing to over 80% of infections, including those caused by Candida species like C. albicans, C. parapsilosis and Candidozyma auris. These species form biofilms on medical devices, making infections challenging to treat, especially with the rise in drug-resistant strains. Candida infections, particularly hospital-acquired ones, are a significant health threat due to their resistance to antifungals and the risk of developing systemic infections (i.e., sepsis). We have previously shown that C14R reduces the viability of C. albicans and C. auris, but not of C. parapsilosis. Here, we show that C14R not only inhibits viability by pore formation, shown in a resazurin reduction

SUBMITTER: Walter JC 

PROVIDER: S-EPMC11939920 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature