Druggable Molecular Networks in <i>BRCA1/BRCA2</i>-Mutated Breast Cancer.

ABSTRACT: Mutations in the tumor suppressor genes BRCA1 and BRCA2 are associated with the triple-negative breast cancer phenotype, particularly aggressive and hard-to-treat tumors lacking estrogen, progesterone, and human epidermal growth factor receptor 2. This research aimed to understand the metabolic and genetic links behind BRCA1 and BRCA2 mutations and investigate their relationship with effective therapies. Using the Cytoscape software, two networks were generated through a bibliographic analysis of articles retrieved from the PubMed-NCBI database. We identified 98 genes deregulated by BRCA mutations, and 24 were modulated by therapies. In particular, BIRC5, SIRT1, MYC, EZH2, and CSN2 are influenced by BRCA1, while <

SUBMITTER: Carbone FP 

PROVIDER: S-EPMC11940086 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature