Development of a miRNA-Based Model for Lung Cancer Detection.

ABSTRACT:

Background

Lung cancer is the leading cause of cancer-related mortality globally, with late-stage diagnoses contributing to poor survival rates. While lung cancer screening with low-dose computed tomography (LDCT) has proven effective in reducing mortality among heavy smokers, its limitations, including high false-positive rates and resource intensiveness, restrict widespread use. Liquid biopsy, particularly using microRNA (miRNA) biomarkers, offers a promising adjunct to current screening strategies. This study aimed to evaluate the predictive power of a panel of serum miRNA biomarkers for lung cancer detection.

Patients and methods

A case-control study was conducted at two tertiary hospitals, enrolling 82 lung cancer cases and 123 controls. We performed an extensive litera

SUBMITTER: Poh KC 

PROVIDER: S-EPMC11940216 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature