How Plant Polyhydroxy Flavonoids Can Hinder the Metabolism of Cytochrome 3A4.

ABSTRACT: Background/Objectives: Recent interest in dietary components and their effects on xenobiotic metabolism has highlighted their role in modulating drug pharmacokinetics. Cytochrome P450 3A4, a key isoform of the cytochrome P450 superfamily, is involved in the metabolism of over 50% of xenobiotics. Flavonoids, present in various foods and supplements, exhibit diverse biological activities influenced by the structural modifications in their scaffold. Methods: Fifteen polyhydroxy-flavonoid compounds were firstly tested by a high-throughput fluorimetric method for their ability to inhibit CYP3A4, where scutellarein and gossypetin were assessed for the first time. A molecular docking analysis was performed for the most active inhibitors to gain insight on their interaction with the

SUBMITTER: Vieira CSP 

PROVIDER: S-EPMC11940229 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature