Polyautoimmunity Reflecting Immune Dysregulation in Common Variable Immunodeficiency.

ABSTRACT: Background: Common variable immunodeficiency (CVID) is the most frequent symptomatic inborn error of immunity (IEI) in adulthood. Other than recurrent infections, CVID may present with non-infectious complications such as enteropathy, lymphoproliferation, malignancy, and autoimmune diseases. Patients could have a single autoimmune disease (monoautoimmunity) or two or more autoimmune diseases (overt polyautoimmunity). "Latent polyautoimmunity" corresponds to the presence of autoantibodies without a clinically evident autoimmune disease. Methods: The aim of this retrospective study was to describe autoimmunity and polyautoimmunity in a population of 81 CVID adult patients, enrolled from January 2008 to July 2022 (mean follow-up: 8.5 years). Results: We documented at leas

SUBMITTER: Danieli MG 

PROVIDER: S-EPMC11940294 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature