CCR2 Regulates Referred Somatic Hyperalgesia by Mediating T-Type Ca²⁺ Channel Currents of Small-Diameter DRG Neurons in Gastric Ulcer Mice.

ABSTRACT: Background: Referred pain frequently co-exists with visceral pain. However, the exact mechanism governing referred somatic hyperalgesia remains elusive. Methods: By injecting 20% acetic acid into the stomach, we established a mouse model of gastric ulcer (GU). Hematoxylin and eosin (H&E) staining was used as the evaluation criterion for the gastric ulcer model. Evan's blue (EB) and von Frey tests detected the somatic sensitized area. The DRG neurons distributed among the spinal segments of the sensitized area were prepared for biochemical and electrophysiological experiments. The CCR2 antagonist was intraperitoneally (i.p.) injected into GU mice to test the effect of blocking CCR2 on somatic neurogenic inflammation. Results: GU not only instigated neurogenic plasma ext

SUBMITTER: Yuan Z 

PROVIDER: S-EPMC11940306 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature