Investigating Modifiable Factors Associated with Cognitive Decline: Insights from the UK Biobank.

ABSTRACT: Objectives: Given the escalating global prevalence of age-related cognitive impairments, identifying modifiable factors is crucial for developing targeted interventions. Methods: After excluding participants with dementia and substantial missing data, 453,950 individuals from UK Biobank (UKB) were included. Cognitive decline was assessed across four cognitive domains. The top 10% exhibiting the greatest decline were categorized as the "Cognitively At-Risk Population". Eighty-three potential factors from three categories were analyzed. Univariate and multivariate Cox proportional hazards models were employed to assess the independent and joint effects of these factors on cognitive decline. Population Attributable Fractions (PAFs) were calculated to estimate the potential impac

SUBMITTER: Ma X 

PROVIDER: S-EPMC11940320 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature