Downregulation of Parahippocampal Copper Chaperone for Superoxide Dismutase in Alzheimer's Disease.

ABSTRACT:

Background/objectives

Proper regulation of copper is essential for maintaining neuronal stability and is facilitated by several chaperone proteins, protecting cells from oxidative damage that would otherwise be caused by improperly regulated copper ions. Oxidative stress, resulting from such dysregulation, is hypothesized to play a significant role in the pathogenesis of Alzheimer's disease (AD).

Methods

In this study, we evaluated the concentrations of the copper chaperones CCS, DCTN4, and ATOX1 in control and AD cases via Western blotting and ELISA, and quantified the copper concentrations in fractionated neurons using ICP-MS.

Results

Our findings reveal a significant reduction in CCS levels in AD cases (p = 0.0085), with a progressive decline observed with a

SUBMITTER: Sanchez N 

PROVIDER: S-EPMC11940324 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature