E-Cadherin Is Important in the In Vitro Postnatal Development and Function of Pig Islets.

ABSTRACT: Background: Pig islets have the potential to address the limited supply of human islets available for transplantation. However, the knowledge of the biology of pig islets is currently limited. Thus, this study evaluated the molecules involved in cell-to-cell adhesion and insulin secretion pathways during the in vitro development of neonatal pig islets to understand the tissue we hope to use as a possible solution to the shortage of human islets for transplantation. Methods: Through RT-qPCR, immunoassays, and assessments of islet function, we explored the expression of E-cadherin and its correlation with the molecules involved in the insulin secretion pathway including GTPase, RAC1, and the membrane fusion protein SNAP25 during neonatal pig islet development. Results: D

SUBMITTER: Purich K 

PROVIDER: S-EPMC11940345 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature