Application of Thyroid Hormones in Women's Hair for the Non-Invasive Prediction of Graves' Disease.

ABSTRACT: Graves' disease (GD) is an autoimmune disorder that can be difficult to distinguish from other diseases due to symptom similarity. The exacerbation of GD owing to delayed diagnosis is a serious issue, and a novel accessible health screening system is needed. Therefore, this study investigated the association between GD and thyroid hormone levels in women's hair and evaluated the prediction accuracy of this non-invasive type of sample. By optimizing pretreatment and analysis techniques using liquid chromatography-mass spectrometry (LC-MS), free triiodothyronine (FT3) and thyroxine (FT4) could be detected in only 2 mg of hair with high sensitivity. Compared with healthy controls, the thyroid hormone levels in the hair of GD patients were significantly higher in correlation with blood levels.

SUBMITTER: Igarashi K 

PROVIDER: S-EPMC11940391 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature