An Antimicrobial and Antifibrotic Coating for Implantable Biosensors.

ABSTRACT: Biofouling and foreign body responses have deleterious effects on the functionality and longevity of implantable biosensors, seriously impeding their implementation for long-term monitoring. Here, we describe a nanocomposite coating composed of a cross-linked lattice of bovine serum albumin and pentaamine-functionalized reduced graphene that is covalently coupled to antibody ligands for analyte detection as well as antibiotic drugs (gentamicin or ceftriaxone), which actively combats biofouling while retaining high electroconductivity and excellent electrochemical immunosensor behavior. Sensors overlaid with this coating inhibit the proliferation of Pseudomonas aeruginosa bacteria and adhesion of primary human fibroblasts while not having any significant effects on fibroblast viabili

SUBMITTER: Wareham-Mathiassen S 

PROVIDER: S-EPMC11940466 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature