Low GCNT2/I-Branching Glycan Expression Is Associated with Bladder Cancer Aggressiveness.

ABSTRACT: Background/Objectives: Abnormal glycan formation on the cancer cell surface plays a crucial role in regulating tumor functions in bladder cancer. In this study, we investigated the roles of glucosaminyl (N-acetyl) transferase 2 (GCNT2) in bladder cancer progression and immune evasion. GCNT2 synthesizes I-branched polylactosamine chains on cell surface glycoproteins. Understanding its functions will provide insights into tumor-immune interactions, facilitating the development of effective immunotherapeutic strategies. Methods: GCNT2 expression levels in bladder cancer cell lines and patient tumor samples were analyzed via quantitative polymerase chain reaction and immunohistochemistry. GCNT2 functions were assessed via overexpression and knockdown experiments. Its effec

SUBMITTER: Tobisawa Y 

PROVIDER: S-EPMC11940493 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature