Antivirulence Properties of Kuraridin Against Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA).

ABSTRACT: Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a major human opportunistic pathogen that causes a wide range of infections. The vast arsenal of virulence factors expressed remains the biggest challenge in treating MRSA with conventional antibiotic therapy. Methods: We investigated the effects of Kuraridin at subinhibitory minimum inhibition concentrations (MICs) of 1/8, 1/16, and 1/32 (concentrations that did not inhibit bacterial growth) on adhesion to fibrinogen, adhesion, internalization into HaCaT cells, and biofilm production in three MRSA strains representing the clonal types USA300, ST30, and ST239. Results: All three MRSA strains exhibited a significant decrease (p < 0.001) in adhesion to fibrinogen upon treatment with 1/8 and 1

SUBMITTER: Barua N 

PROVIDER: S-EPMC11940505 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature