Chemotaxis and Related Signaling Systems in <i>Vibrio cholerae</i>.

ABSTRACT: The motility and chemotaxis of Vibrio cholerae, the bacterial pathogen responsible for cholera, play crucial roles in both environmental survival and infection. Understanding their molecular mechanisms is therefore essential not only for fundamental biology but also for infection control and therapeutic development. The bacterium's sheathed, polar flagellum-its motility organelle-is powered by a sodium-driven motor. This motor's rotation is regulated by the chemotaxis (Che) signaling system, with a histidine kinase, CheA, and a response regulator, CheY, serving as the central processing unit. However, V. cholerae possesses two additional, parallel Che signaling systems whose physiological functions remain unclear. Furthermore, the bacterium harbors over 40 receptors/transduce

SUBMITTER: Omori F 

PROVIDER: S-EPMC11940527 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature