Olfactory Testing and Gray Matter Volume: A Combined Approach to Predict the Conversion to Alzheimer.

ABSTRACT: Background/Objectives: Olfactory decline is common in normal aging and frequent in neurodegenerative diseases such as Alzheimer's disease (AD). Therefore, it has been suggested as a marker for the Mild Cognitive Impairment (MCI) progression to AD. Although suggested, the relationship between olfactory deficits and cerebral atrophy in MCI conversion to AD is still debated. This study aims at investigating the olfaction-related morphological and behavioural alterations in MCI in order to understand whether they can predict the progression to AD. Methods: Twenty-seven MCI patients and thirty-five healthy controls (HCs) took part in the study, with follow-up showing conversion to AD in thirteen patients (converter-MCI, cMCI). The Burgarth Sniffin' Sticks Tests (threshold-TT, disc

SUBMITTER: Casadio C 

PROVIDER: S-EPMC11940542 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature