The Role of Chemotherapy in Patients with Synchronous Colorectal Liver Metastases: A Nationwide Study.

ABSTRACT:

Background/objectives

There is still no consensus as to whether patients with upfront resectable synchronous colorectal liver metastases (sCRLM) should receive neoadjuvant treatment prior to liver surgery. Two randomized controlled trials have assessed the role of peri-operative chemotherapy in sCRLM; neither have shown a survival benefit in the neoadjuvant group. The aim of this population-based study was to examine overall survival in patients treated with neoadjuvant chemotherapy and hepatectomy compared to patients who had upfront surgery.

Methods

This is a retrospective observational study between 2009 and 2017 containing data extracted from two Swedish national registries. Descriptive statistics and Cox regression analyses were employed.

Results

In total, 2072 p

SUBMITTER: Sternby H 

PROVIDER: S-EPMC11940559 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature