Neural correlates of frailty in cognitively healthy adults: A multimodal imaging study.

ABSTRACT:

Objective

Frailty has emerged as prevalent condition in ageing. While frailty has been assessed through physical and functional criteria, recent studies have explored the link between cognitive decline and frailty, which remains complex and warrants further investigation. Our aims were to compare differences at the brain level between robust and frail older people without dementia and to explore possible associations between brain measures and cognitive performance assessed with neuropsychological tests.

Methods

Using data from the "CAM-Cam" project that recruited a community dwelling population, we identified robust and frail participants based on the Rockwood Frailty index. Magnetic Resonance Imaging was performed to probe the interplay between physical frailty and cogniti

SUBMITTER: Parrotta I 

PROVIDER: S-EPMC11940682 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature