Cortical Origin-Dependent Metabolic and Molecular Heterogeneity in Gliomas: Insights from ¹⁸F-FET PET.

ABSTRACT: Objectives: The objective of this study is to explore the potential variations in metabolic activity across gliomas originating from distinct cortical regions, as assessed by O-(2-¹⁸F-fluoroethyl)-L-tyrosine positron emission tomography (¹⁸F-FET PET). Also, this study seeks to elucidate whether these metabolic disparities correlate with the molecular characteristics and clinical prognoses of the tumors. Specifically, this research aims to determine whether variations in ¹⁸F-FET PET uptake are indicative of underlying genetic or biochemical differences that could influence patients' outcomes. Methods: The researchers retrospectively included 107 patients diagnosed with gliomas from neocortex and mesocortex, all of whom underwent hybrid PET/MR e

SUBMITTER: Diao H 

PROVIDER: S-EPMC11940755 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature